MEDICAL SCIENCE
Imatinib Therapy In Chronic Myeloid Leukemia : A Brief Overview
by Dr. Namrata Bhutani
ISBN Number : 978 - 93 - 88672 - 47 - 4
Authors Details
| Author Name | Image | About Author |
|---|---|---|
| Dr. Namrata Bhutani |  |
Dr.Namrata Bhutani is Senior Resident in Department of
Biochemistry at Vardhaman Mahavir Medical College &
Safdarjung Hospital, New Delhi. She has completed MBBS
from the prestigious Lady Hardinge Medical College, New
Delhi , after which she continued her passion in biochemistry
by doing MD BIOCHEMISTRY from Maulana Azad
Medical college, New Delhi. She has done research work in
chronic myeloid leukemia as part of her MD degree. |
Book Description
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. It is characterized by the the Philadelphia (Ph) chromosome, which occurs due to a balanced reciprocal translocation between chromosome 9 and 22 t(9;22)(q34.1;q11.2). It was the first malignancy that had a specific chromosomal abnormality uniquely linked to it. This chromosomal abnormality is so named because it was first discovered and described in 1960 by two scientists from Philadelphia, Pennsylvania: Peter Nowell of the University of Pennsylvania and David Hungerford of the Fox Chase Cancer Center at Temple University.(Nowell-PC).8 In 1973, Janet D. Rowley at the University of Chicago identified the mechanism by which Philadelphia chromosome arises as a translocation.
